Liverpool are leading the Portugese side 5-0 on aggregate, with goals from Mohamed Salah, Roberto Firmino and a hat trick from Sadio Mané leaving the Merseyside club in control ahead of their 7.45pm kick off at Anfield.
The team news for the second leg is as follows:
Liverpool XI: Karius, Gomez, Matip, Lovren, Moreno, Henderson, Milner, Can, Lallana, Mane, Firmino.
Substitutes: Mignolet, Van Dijk, Salah, Klavan, Oxlade-Chamberlain, Ings, Alexander-Arnold.
A relatively strong lineup from Klopp, with Moreno, Matip, Milner, Lallana and Gomez, the five changes from their 2-0 win against Newcastle at the weekend.
#UCL team news... https://t.co/5rVaVEyNIn pic.twitter.com/LQJiOquhXV
— Liverpool FC (@LFC) March 6, 2018
Champions League nights at Anfield. ? pic.twitter.com/tG5VhRwDRR
— Liverpool FC (@LFC) March 6, 2018